By J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle
Every one quantity of Advances in Pharmacology presents a wealthy number of experiences on well timed themes. Emphasis is put on the molecular bases of drug motion, either utilized and experimental.
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Arg-Lys-Arg-Arg) cleavage sites in the protein. , 1994). Detailed biochemical analysis of the MMTV Sag has been hampered by its low abundance in cells. The sag genes of the various M t u loci are very homologous at both the nucleotide and the amino acid level except for their 30 C-terminal amino acids (Fig. 4B), which have been called the hypervariable domain. , 1993). Indeed, the different M t u and MMTV Sag proteins can be grouped together by the sequences of their hypervariable domain; Sag proteins that fall into the same group generally interact with the same VP-bearing T cells (Fig.
Varnum, B. , Lim, R. , and Henchman, H. R. (1991). TISIO, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthasekyclooxygenase homologue. J . Biol. Chem. 266, 1286612872. Kune, K. , and Watson, L. F. (1988). Colorectal cancer risk, chronic illnesses, operations, and medications: Case control results from the Melbourne Colorectal Cancer Study. Cancer Res. 48, 4399-4404. , and Attali, P. Sulindac causes regression of rectal polyps in familial adenomatous polyposis.
Nonsteroidal anti-inflammatory drug use and sporadic colorectal adenomas. Gastroenterology 108, 1310-1 314. DuBois, R. , Awad, J. , and Lanahan, A. (1994). Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells. Am. J. Phys. 266, G822-G827. DuBois, R. , and Beauchamp, R. D. (1996). G, delay in intestinal epithelial cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res. 56, 733-737. Eberhart, C. , Coffey, R. , Radhika, A,, Giardiello, F.