Allergic Diseases by Patterson

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The presence of these additional modulatory pathways suggests that mast cell and basophil mediators participate in inflammatory conditions in hich IgE may not be present. MEDIATORS Whatever their final metabolic interrelationships, the early biochemical processes lead to the generation of a heterogenous group of molecules termed mediators. Some mediators are preformed and are stored in the granules of the cell; others are generated only after cell activation and originate in the cytosol or membrane.

Kay AB. Concepts of allergy and hypersensitivity in allergy and allergic diseases. In: Kay AB, ed. Allergy and allergic diseases. Vol. 1. Oxford, UK: Blackwell Science, 1997;23–35. 4 Biochemical Mediators of Allergic Reactions Patterson’s Allergic Diseases 4 Biochemical Mediators of Allergic Reactions Stephen I. Wasserman Department of Medicine, University of California, San Diego, La Jolla, California, Department of Medicine, University of California, San Diego Medical Center, San Diego, California Mediator-generating Cells Activation of Mast Cells and Basophils Mediators Spasmogenic Mediators Platelet-activating Factor Oxidative Products of Arachidonic Acid Cyclooxygenase Products Lipoxygenase Products Adenosine Chemotactic Mediators Neutrophil Chemotactic Factors Eosinophil Chemotactic Factors Mediators with Enzymatic Properties Structural Proteoglycans Mediator Interactions The Role of the Mast Cell and its Mediators in Tissue Homeostatic Role of Mast Cells Chapter References Recent research has expanded the understanding of the cells and mediators relevant to diseases of immediate-type hypersensitivity.

1st ed. St Louis: CV Mosby, 1978: 551. Johansson SGO, Mellbin T, Vahlquist G. Immunoglobulin levels in Ethiopian preschool children with special reference to high concentrations of immunoglobulin E (IgND). Lancet 1968;1:1118. Barbee RA, Halonen M, Lebowitz M, et al. Distribution of IgE in a community population sample: correlation with age, sex, allergen skin test reactivity. J Allergy Clin Immunol 1981;68:106. Lewis RA, Austen KF. Mediation of local homeostasis and inflammation by leukotrienes and other mast-cell dependent compounds.

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