Antigen Delivery Systems: Immunological and Technological by Bruno Gander, Hans P Merkle, Giampietro Corradin

By Bruno Gander, Hans P Merkle, Giampietro Corradin

This article offers an updated review of modern advancements during this box, studies new developments in vaccine improvement courses, and emphasizes the necessities and value of assorted vaccine supply structures.

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Eur. J. , 25, 2211–2219. J. L. (1995) How MHC class II molecules reach the endocytic pathway. Eur. Mol. Biol. Org. , 14, 37–49. , Benaroch, P. L. (1994) Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. Eur. Mol. Biol. Org. , 13, 2699–2707. L. C. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature, 329, 506–512. , Bettens, F. J. (1993) Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide.

J. L. (1995) How MHC class II molecules reach the endocytic pathway. Eur. Mol. Biol. Org. , 14, 37–49. , Benaroch, P. L. (1994) Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. Eur. Mol. Biol. Org. , 13, 2699–2707. L. C. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature, 329, 506–512. , Bettens, F. J. (1993) Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide.

Each antibody clone binds with high affinity one antigenic structure and ignores the others, even related ones. By contrast, each type of MHC molecule binds with high affinity a large array of different peptides. However, a too promiscuous binding would restrict the size of the T cell repertoire because of the elimination of too many T cells which would detect MHC molecules having bound peptides derived from the organism itself. The paradox of “high affinitypromiscuous” binding was solved by the observation that the peptides mainly rely on atoms of the main chain for binding, rather than on sequence specific structures, that is side chains of amino acids.

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