Asymmetric Synthesis of Non-Proteinogenic Amino Acids by Ashot S. Saghyan, Peter Langer

By Ashot S. Saghyan, Peter Langer

Authored by means of across the world well-known specialists with an outstanding music checklist, this much-needed reference summarizes most up-to-date learn within the swiftly constructing box of stereoselective synthesis of enantiomerically enriched amino acids, quite of non-proteinogenic beginning. It highlights numerous varied catalytic and stoichiometric uneven equipment for his or her synthesis and in addition presents info on beginning, organic homes, varied man made thoughts and significant purposes in drugs and pharmacology.
Essential studying for artificial chemists operating within the box of uneven synthesis, normal items and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.

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Chem. , 5, 1081. 33 35 3 Systems for Modeling Some Aspects of Pyridoxal Enzyme Action Much of what is known about the pyridoxal catalysis is obtained based on the studies of model systems containing pyridoxal, metal ions, and amino acid. One of the first in this respect are the studies of Snell and his students who showed that serine and cysteine in the presence of metal ions and pyridoxal in neutral, acidic, and alkaline environments converted to pyruvic acid [1–3]. Furthermore, it was shown that under the same conditions pyruvic acid was formed by other β-substituted α-amino acids: phosphothreonine [4], phosphoserine [5–7], β-chloro-α-aminobutyric acid [6, 7], β-chloroalanine [6, 7], S-ethylcysteine [7], S-phenylcysteine [8].

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Ed. , 16 (5), 328. References 19. , and Friedman, M. (1976) Int. J. Pept. , 8 (1), 57. 20. Schmidt, U. and Ohler, E. (1977) Angew. Chem. Int. Ed. , 15 (1), 42. 21. , and Kuzuhara, H. (1982) Chem. , 11 1765. 22. H. (1974) Biochem. Biophys. Acta, 362, 308. 23. K. H. (1979) J. Am. Chem. , 101 (10), 2781. 24. T. (1977) Tetrahedron, 33 (19), 2551. 25. , and Weintraub, J. (1978) Biochemistry, 17 (16), 3177. 41 43 4 Modeling of Processes Associated with Cleavage of C????–H and C????–C???? Bonds As has been previously shown, chiral bis-salicylidene and pyridoxalidene octahedral complexes of SoIII , AlIII , and FeIII ions can be successfully used to simulate and to some extent model the reactivity of pyridoxal-dependent aldolase [1].

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